Compress Data Base error on GloHD

When attempting to compress the data base I get this "database or disc full" error. Any ideas on how to fix? Also getting random WIN7 requests to scan device disc on connect (never any errors).

calibre, version 2.43.0
ERROR: Unhandled exception: <b>OperationalError</b>:database or disk is full

calibre 2.43 [64bit] isfrozen: True is64bit: True
Windows-7-6.1.7601-SP1 Windows ('64bit', 'WindowsPE')
('Windows', '7', '6.1.7601')
Python 2.7.9
Windows: ('7', '6.1.7601', 'SP1', 'Multiprocessor Free')
Successfully initialized third party plugins: K4PC, K4Mac, Kindle Mobi and Topaz DeDRM && Inept Epub DeDRM && Goodreads && Find Duplicates && Reading List && Resize Cover && Quality Check && Inept PDF DeDRM && Ignoble Epub DeDRM && Kobo Utilities
Traceback (most recent call last):
File "calibre_plugins.koboutilities.action", line 1441, in vacuum_device_database
File "calibre_plugins.koboutilities.action", line 3189, in _vacuum_device_database
OperationalError: database or disk is full