Error code 1 - please help

Hi, I'm trying to install Calibre on a new computer, running on Windows 8
I keep getting Error code 1 when trying to launch it

calibre-debug -g shows:

Python function terminated unexpectedly
(3, 'CreateFile', 'The system cannot find the path specified.') (Error Code: 1
)
Traceback (most recent call last):
File "site.py", line 132, in main
File "site.py", line 108, in run_entry_point
File "site.py", line 50, in load_module
File "site-packages\calibre\__init__.py", line 21, in <module>
File "site.py", line 50, in load_module
File "site-packages\calibre\startup.py", line 77, in <module>
File "site-packages\calibre\utils\localization.py", line 129, in set_translato
rs
File "site-packages\calibre\utils\localization.py", line 63, in get_lang
File "site.py", line 50, in load_module
File "site-packages\calibre\utils\config_base.py", line 448, in <module>
File "site-packages\calibre\utils\config_base.py", line 357, in __setitem__
File "site-packages\calibre\utils\config_base.py", line 371, in set
File "site-packages\calibre\utils\config_base.py", line 300, in set
File "site-packages\calibre\utils\lock.py", line 140, in __enter__
File "site-packages\calibre\utils\lock.py", line 32, in __init__
pywintypes.error: (3, 'CreateFile', 'The system cannot find the pathspecified.')
D:\Calibre\pylib.zip\calibre\ptempfile.py:35: RuntimeWarning: Parent module 'calibre' not found while handling absolute import

The system cannot write to the specified device.


Can anyone help?